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Stephen W. Kuffler was a scientist in the fields of neurobiology, neurophysiology, and neuroscience.
Stephen was born on August 24th, in Hungary. He left this life on October 11th, Johannes was born in He passed away in The map shows the absolute popularity of the name Kuffler as a last name in each of the states.
See other popular names in Kansas , New York , or California. I do not know how you feel about it, but you were a male in your last earthly incarnation.
You were born somewhere around the territory of Poland approximately on Your profession was builder of roads, bridges, and docks.
You were a person with huge energy, good in planning and supervising. If you were just a garbage-man, you were chief garbage-man.
You are bound to solve problems regarding pollution of environment, recycling, misuse of raw materials, elimination of radioactivity by all means including psychological methods.
Advanced Search. Toggle navigation. Name Poster Keep scrolling for more. Last Name in the U. Kuffler was widely recognized as a truly original and creative neuroscientist.
In addition to numerous prizes, honorary degrees, and special lectureships from countries over the world, Steve was elected to the National Academy of Sciences in and to the Royal Society as Foreign Member in In he was named the Robert Winthrop professor of neurophysiology and neuropharmacology.
From to he was the Robert Winthrop professor of neurobiology, and in he became John Franklin Enders university professor.
Kuffler, compiled and introduced by U. McMahan Sunderland, Mass. He was particularly happy at home where he had the free run of the estate; he greatly enjoyed horseback riding.
At school Steve studied humanities, Latin, and Greek, but virtually no science. In he went to medical school in Vienna; while he was a student his circumstances changed drastically when the family fortune was lost.
The suddenness of this change from affluence to financial hardship had a profound effect on his view of life. During his training in medicine which he was able to continue, albeit under straitened circumstances , he visited Egypt and England, which he enjoyed, except for a brief stint at the German Hospital in London.
Steve found the atmosphere there to be authoritarian, repugnant, and reminiscent of the political atmosphere in Vienna with the growing intolerance and brutality that accompanied Nazism.
After finishing his medical examinations in , he worked in the Department of Pathology. Steve's distress at the situation after the Anschluss came to a head when he found that he had to do a postmortem on a colleague of his who had been murdered by the Nazis.
After spending a few months in England he went to Australia, and it was there that his life as an experimen-. The key catalytic event in Steve's scientific development was the arrival of Bernard Katz later Sir Bernard Katz, Nobel Prize winner who came to Eccles's lab in late From the very beginning Steve formed a close and long lasting friendship with Bernard Katz.
Although Steve was to develop his own highly characteristic style of experimental research, Bernard Katz remained as the neuroscientist who most influenced his standards for the conduct of scientific research.
In Eccles's lab Steve on his own made his first experiments on isolated nerve muscle junctions, which Bernard Katz described as ''a brilliant technical feat.
In addition to doing his own research he recruited a group of brilliant, independent young scientists, including David Hubel, Torsten Wiesel, Edwin Furshpan, and David Potter, together with an outstanding electronics engineer, Robert Bosler, with whom he was to work closely for the rest of his life.
Steve also began to spend summers at the Marine Biological Laboratory at Woods Hole with his family and co-workers and started the first experimental lab courses devoted to the nervous system the "Nerve-Muscle Program," later to become the neurobiology course.
These intense lab and discussion courses had immense influence on generations of young graduate students and postdoctoral fellows coming from a variety of disciplines.
In the entire laboratory moved to the Department of Pharmacology at Harvard Medical School at the invitation of Prof.
Otto Krayer, who offered generous space and facilities. At Harvard, Steve recruited a young biochemist, Edward Kravitz.
A major contribution to the study of the nervous system was Steve's innovative idea of combining physiology, biochemistry, histology, neuroanatomy, and electron microscopy in one single group.
In this way he shifted the focus of research from techniques that had been located in separate departments in universities throughout the world to neurobiology, a concept that Steve invented.
From the time that the Department of Neurobiology was created in with Steve as chairman, he continued until his death to work in the lab with one or two postdoctoral fellows.
Summers were spent at Woods Hole, except for the years to , which were spent at the Salk Institute in La Jolla.
Throughout his career, Steve provided the impetus for much of the research by his co-workers and criticized their papers in a light but decisive, inimitable style.
Steve's name, however, appeared as author only on those papers in which he had done the experiments with his own hands.
In the following paragraphs I summarize briefly highlights of Steve's research in roughly chronological order. Steve's style of research from the outset was to locate the Gordian knot and then cut right through it.
By dissecting a single skeletal muscle fiber together with its nerve—an immensely difficult task—Steve could analyze the events occurring at the synapse with greater precision than had hitherto been possible in intact muscles.
At a time when. As a student, I well remember reading each new paper with excitement and admiration. Other experiments with Bernard Katz on crustacean muscles set the stage for later important studies on inhibition.
Steve's initial work in Chicago was on slowly contracting muscle fibers in the frog and this in turn led him to the study of the sensory innervation of mammalian muscle.
Although important pioneering studies had been made on sensory muscle spindles by B. Matthews in the early s and by L. Leksell in the mids, the literature about the efferent output from the spinal cord to the spindle was abundant but confused and largely incomprehensible.
This was the usual starting point for Steve's generation of a new idea. At Hopkins, together with Peter Quilliam and Cuy Hunt with whom he was to develop a close friendship and work for several years, he devised an elegant and direct experiment.
Electrical recordings were made from a single sensory fiber coming from a muscle spindle receptor in muscle. At the same time an individual motor nerve fiber was stimulated.
A large fiber, as expected, caused muscle contractions. When a single small diameter motor fiber was stimulated there was no overt contraction of the muscle, but the stimuli dramatically increased the frequency of the sensory discharge.
This was due to activation of small specialized muscle fibers in the muscle spindle. In a series of elegant papers Cuy Hunt and Steve explored in detail the role of this efferent control by the nervous system of the information coming to it.
In the next series of experiments at Hopkins, Steve turned to signaling in the mammalian retina. In it was impossible to understand the meaning of signals traveling from the eye to the brain.
This was in large part because bright flashes of diffuse white or colored light had been used as stimuli. Through the invention with his friend S.
Talbot of a new ophthalmoscope, Steve was able to stimulate well-defined discrete areas of retina by small, light, or dark spots.
Once again in one series of experiments in which he was sole author, Steve revealed a fundamental mechanism. A key feature was to use natural stimuli to define the receptive field properties of individual ganglion cells and their optic nerve fibers.
The major conclusion was that these cells responded primarily to contrast and to moving stimuli rather than diffuse light. These properties in turn depended on the convergence of excitatory and inhibitory inputs arising from cells in preceding layers of the retina.
A story Steve told me shows the impact of these retina papers. Steve had just presented his new findings at a meeting in Cambridge.
Lord Adrian, the pioneer in our understanding of sensory signaling whom Steve greatly admired but had never met, was walking along a corridor from the other direction.
As he encountered Steve he stopped, cocked his head, and asked simply, "Are they the same in the brain? In , Farming and Housekeeper were the top reported jobs for men and women in the US named Kuffler.
View Census data for Kuffler Data not to scale. There are 1, census records available for the last name Kuffler. Like a window into their day-to-day life, Kuffler census records can tell you where and how your ancestors worked, their level of education, veteran status, and more.
There are immigration records available for the last name Kuffler. Passenger lists are your ticket to knowing when your ancestors arrived in the USA, and how they made the journey - from the ship name to ports of arrival and departure.
There are military records available for the last name Kuffler. For the veterans among your Kuffler ancestors, military collections provide insights into where and when they served, and even physical descriptions.
Between and , in the United States, Kuffler life expectancy was at its lowest point in , and highest in The average life expectancy for Kuffler in was 50, and 90 in